Cardiac tissue repair - Cormatrix™

Om CorMatrix® ECM® Teknologi

CorMatrix ECM Technology is a unique extracellular matrix that combines the innate attributes of nature with the precision of science to help the heart heal itself. It is an acellular biomaterial that does not encapsulate when surgically implanted, but is gradually remodeled, leaving behind organized and healthy tissue.

The body’s tissue begins remodeling at the surgical site while the ECM maintains the needed tissue support. When implanted, the ECM acts as a scaffold into which the patient’s cells migrate and integrate, stimulating the patient’s natural wound-healing mechanisms.

As the patient’s cells become active, they lay down their own collagen, which matures over time to form strong and permanent tissue repair without leaving behind permanent foreign material. Because the ECM contains primarily collagen, the device is gradually replaced as the patient’s tissue gradually turns over in a natural state of self-renewal.

CorMatrix ECM Technology

CorMatrix ECM Technology is a platform innovation with multiple cardiovascular applications.

This naturally occurring extracellular matrix biomaterial supports native tissue repair by providing an interim bioscaffold, that enables a patient’s own cells to repopulate and repair damaged tissues.

CorMatrix ECM for Pericardial Closure

CorMatrix ECM for Pericardial Closure is intended for the reconstruction and repair of the pericardium. CorMatrix ECM allows cells to infiltrate the ECM to remodel and form a new pericardial layer. Preclinical data suggests that reformation of the pericardial space, complete with an intact mesothelial lining, provides a solution for surgeons to reconstruct the pericardium and restore the normal anatomic structure.

CorMatrix ECM for Cardiac Tissue Repair

Marc Gerdisch, MD, Director of Cardiothoracic Surgery at the St. Francis Heart Center, Indianapolis

CorMatrix ECM is ideal for intracardiac surgery based on its ability to remodel tissue. In cases such as atrial septal defect repair, CorMatrix ECM can effectively close a hole and generate new, healthy tissue in lieu of using objects such as nitinol plugs or synthetic patches. Because the tissue is remodeled, there is no foreign material left behind as is the case with more traditional repair materials.

The ECM composition provides the right environment for native cells to be recruited to the area of repair. Over time the ECM is remodeled and resorbed as new tissue develops. CorMatrix ECM is routinely used for:

• Suture line reinforcing
• Buttressing for soft tissue reapproximation
• Pledgets
• Aortic cannulation sites
• Cardioplegia cannulation sites
• Right atrium cannulation sites
• Aortotomy reinforcement
• Ventricular reinforcement
• Septal defect repair

   

For more information www.cormatrix.com